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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
@Gordon
You'd have to look at the reference manual for the STM32F411 to see for sure how it did it, but the hardware does handle it and I'm pretty sure it's enabled. The 411's I2C should be pretty much identical to the 401 (for the Pico) mentioned in this thread.
Software I2C should also handle it, so you could try that and see what happens? https://github.com/espruino/Espruino/blob/master/src/jsi2c.c#L62