Lora and Espruino

Have you seen this page? https://www.espruino.com/RN2483

That'll get you connected to the RN2483, and then it's a matter of connecting to LoRa.

It should be as easy as:

var RN2483 = require("RN2483");
Serial1.setup(57600, { tx:B6, rx:B7 });
var lora = new RN2483(Serial1, {reset:B3});
/* configure the LoRaWAN parameters
 devAddr = 4 byte address for this device as hex - eg. "01234567"
 nwkSKey = 16 byte network session key as hex - eg. "01234567012345670123456701234567"
 appSKey = 16 byte application session key as hex - eg. "01234567012345670123456701234567"
*/
lora .LoRaWAN = function (devAddr, nwkSKey, appSKey, function() {
  console.log("connected!");
  lora.loraTX("Hello", function() {
   console.log("sent!");
  });
});

But I don't have a LoRa base station set up here to test with I'm afraid. I'll see if there's anyone that has had it working that can confirm.