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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
@Gordon
Sorry for the delay - I've been on holiday the past week.
As @DrAzzy says, I'd be pre-installing the ESP8266 (as the idea is to get something a bit more plug-and-play), so I'm afraid I don't think tweaking the pinout would really help that much.
But you could make what we're calling a shim - basically a bit of PCB with a Pico pinout on one side, and some module on the other. There is already one for RFM69/RFM12B...
It wouldn't be quite as small, but it wouldn't be that far off...