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@Gordon
@Stev - it sounds to me like you may have some other software using that serial port? Have you tried on a different computer?
The serial bootloader itself is built into the STM32 in read-only memory, so either the STM32 chip is defective (seems unlikely) or something else is padding those bytes out.
Of course I guess it could be a hardware fault - maybe the connections between the STM32 and the PL2303 are a bit flaky?