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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
Mihis
You definitely can (assuming it's a 3.3v friendly shield, which it should be), however I'm not 100% sure how easy it will be.
There are a bunch of modules for Quectel modems: http://www.espruino.com/Search?kw=quectel
And this is another NB-IoT modem, so should hopefully work: http://www.espruino.com/QuectelBG96
If the instructions there work, you could then just use the MQTT module from http://www.espruino.com/MQTT alongside it