Pixl.js + Arduino shields

Any ideas what the library would actually do? Realistically I'm not going to be able to add drivers for 450 different boards :)

Why not? ;-)

I was only thinking about really small code examples for setting up the communication interfaces (UART, SPI or I2C) on the correct pins. Or even better, a kind of abstraction layer for modules compatible with the "mikroBUS" (spec here: https://download.mikroe.com/documents/standards/mikrobus/mikrobus-standard-specification-v200.pdf)
In page 6 is showed the pinout of the mikroBUS.
I could be very cool to be able to get access to this by calling some thing like

var mikroBUS= new mikroBUS();

digitalPulse(mikroBUS.RST, 1, 5);
mikroBUS.SPI.send("some data");
analogRead(mikroBUS.AN);
//and so on...