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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
@Jean-Philippe_Rey
Maybe a bad output state on RTS/DTR ? Just had a look at the schematic (https://wiki.wemos.cc/_media/products:d1:mini_new_v2_2_0.pdf) and saw that those signals can have control of RST pin (see U4 on the PDF).