On Windows you can actually get to the point where you have plugged too many devices into your PC at one point or another, and there are no more COM ports available! There's a webpage with a fix for it here
Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
Also, are you on Windows?
Have you looked at the steps here? http://www.espruino.com/Troubleshooting
On Windows you can actually get to the point where you have plugged too many devices into your PC at one point or another, and there are no more COM ports available! There's a webpage with a fix for it here