Just quickly googled this, and it looks like the C64 has RS232 on the user port, but probably at 5v levels. There's a page here with info on how to wire the level shifter.
But it looks like you could wire a Pico directly to a user port connector if you wanted - no level shifting needed :)
Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
Just quickly googled this, and it looks like the C64 has RS232 on the user port, but probably at 5v levels. There's a page here with info on how to wire the level shifter.
But it looks like you could wire a Pico directly to a user port connector if you wanted - no level shifting needed :)