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Thank you @Gordon and @AkosLukacs for your comments.
Very helpful.
Thanks very much

Hi I see the MDBT42Q Breakout uses the only UART for serial console.

I'd like to use an RN2483A (I've a breakout board from tindie [1] on the way)

Will it be possible in JS code to claim the UART for interfacing with this peripheral, and use the BLE interface for consoe/firmware/script upload.

Some thoughts:
a) I notice it checks the status of the MCU:RX <-- TX line.
I assume the RN2483 isn't going to boot up with TX high (but that could be a gross presumption)

b) Can the BLE radio be disabled in code? I would only need the radio on for config/update, it'd be nice to shut the radio down.

c) What's the deep sleep current like on the MDBT42Q breakout compared to the Pico.
I was going to use the pico but some off the PPI features look really interesting.

Thanks.

R

[1] https://www.tindie.com/products/drazzy/rn2483-breakout-bare-board/