It sounds like if it is possible at all CPU-wise it will be awfully close. Probably too close for someone (Nordic) to attempt to implement newer bluetooth LE codecs on these chipsets. If it somehow actually works, storage would be the next big problem. 8MB flash is not much to store audio samples.
Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
Does it mean nrf5340 would drain the battery when working with audio?