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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
@fanoush
someone have tested serial and i2c over same pins with ds-d6 fitness tracker (which only have 2 gpios available without taking it apart and by default it is serial console) and switching to i2c worked fine. ttl serial is high when idle so pull up configuration should be similar with i2c and ttl serial.
I guess it uses just internal configurable pull ups and not resistors on board but even if there are pull up resistors in ds-d6 the requirement for them should be similar for i2c and serial (?) so in general this combination should work.