I haven't heard of anyone doing it, but I think it's possible. I believe those things need active scanning - probably not easy to do for greyscale without custom firmware, but I think you could scan out with 3 bit colour from JS.
I'd look at http://www.espruino.com/LPD6416 - it uses this module: http://www.espruino.com/modules/LPD6416.js
You'd need to add the extra colour channel and more rows, but I think that could be ok. The only think is it'd likely flicker if other JS code took more than 20ms or so to execute, but it's definitely usable (and there are some other hacks you could do with inline C as well that might fix that).
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