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With v77 of Espruino firmware, it should be as simple as wiring up a uSD breakout board, and making one extra function call before doing the filesystem calls (v76 for pico wasn't built with the support enabled - this omission is fixed).
Using sd card on Espruino is simple, and you get oodles of space for cheap, and it's super easy to transfer to computer. It's great for datalogging. It's less ideal if you're storing data and then later using it on the Espruino - you can do it, but it's more awkward than an EEPROM.
Neither EEPROM or SD card is hard to interface with on Espruino.
No issue other than I thought avoiding it might be easier. I'm probably wrong.