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Espruino is a JavaScript interpreter for low-power Microcontrollers. This site is both a support community for Espruino and a place to share what you are working on.
@gadicc
I'd say it's doable with a bit of work. You could create a new transport layer over serial (using a node serial module on the Meteor side), and plug into the respective parts on each side. Call a function on the Espruino when sending data, and ensure data comes back via console.log() and is handled accordingly on the Meteor side. It's not simple but definitely doable.
Quite a weird setup though. It will be permanently tethered to your PC? I'd say if you don't want wifi, but are fine with a cable, make it an ethernet cable :>
Possibly better handled with a small node app that uses the above approach to accept http connections and forwards them over serial. That has greater application for the general community as a whole too.