• Do you have in mind a F4 board

    Not really. However http://www.espruino.com/STM32L496GDISCOV­ERY has a bunch of pins, is fast, and has loads of RAM.

    I was wondering if there's any USB stack on the nRF boards or the MDBT42Q ?

    No, there's no USB at all on the nRF52832. There is on the nRF52840, but apart from a few test builds I have nothing targeting those, and while I had a USB serial test, USB HID gamepad support is miles off.

    how to know if padding is allowed by GCC ?

    You could just print sizeof(your_struct)?

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